Become a Natural Health Professional! – If you would like to learn Reflexology, Color Therapy, Crystal Therapy or Aromatherapy at your own pace in your own home, please visit the Alternative Healing Academy. We offer a wide range of comprehensive holistic health courses at affordable prices. We even offer payment plans!
Home » Health and Vitality

Don’t Combine SSRI Anti-Depressants With NSAIDs, Aspirin, Motrin Etc.

[5 Aug 2011 | No Comments | | Author: ]
If you enjoy this post, please share it using the buttons in the post, or email it to a friend, we'd really appreciate it!





by Warren Matthews of Xtend-Life

Below is a copy of an article which outlines some new information about combining these two forms of drugs and the resultant increased risk of gastrointestinal bleeding.

None of these results are surprising as no one really knows the full extent of interactions between drugs, not even the pharmaceutical companies. I remember talking to scientist from one of the pharmaceutical companies a few years ago and he readily admitted that they have no idea what can happen when two drugs are combined, let alone 5 of more which many people are on.

The Doctors certainly don’t know either as they rely entirely on the published material from the pharmaceutical companies.

Here it is:

A drug from the class of antidepressants called selective serotonin reuptake inhibitors (SSRIs), such as Prozac, Zoloft or Paxil, added to a nonsteroidal anti-inflammatory drug (NSAID), such as Motrin, Aspirin or Celebrex, can interact to increase the risk of upper gastrointestinal bleeding, according to a report in current issue of Alimentary Pharmacology and Therapeutics.

“Before I did this study, I didn’t worry at all when I saw patients who were on combination SSRIs and NSAIDs,” Dr. Yoon K. Loke from the University of East Anglia, Norwich, UK told Reuters Health. “Now that I have seen the fairly substantial excess risk (beyond even what I had imagined beforehand), physicians should carefully review the patients’ charts — do they need to be on these drugs (at all), or are there safer alternatives?”

Loke and colleagues conducted a review to investigate the risk of upper gastrointestinal hemorrhage with SSRIs and to evaluate the possibility of an interaction between SSRIs and NSAIDs contributing to such bleeding.

The researchers analyzed the findings of four studies containing 153,000 patients and found that those taking SSRIs alone had 2.4-times the risk of upper gastrointestinal hemorrhage and those taking NSAIDs alone had 3.2-times the risk. However, in patients taking both SSRIs and NSAIDs the risk of upper gastrointestinal hemorrhage was 6.3-times greater than normal.

Based on these findings, the investigators estimate that a patient would most likely develop a problem after taking an SSRI 318 times per year. However, for those taking both drugs, they would only need to take them 82 times before an adverse evident would occur, Lok’s group predicts.

For those with other risk factors for gastrointestinal bleeding, the number would be even lower, the researchers estimate.

In postmarketing reports to regulatory agencies, the average time to occurrence of upper gastrointestinal hemorrhage was after 25 weeks of SSRI treatment, with 38 percent of the reported cases occurring in patients younger than 60 years.

“Fewer people might be harmed from drug overdose with SSRIs (than with tricyclic antidepressants), but this is very likely to be counterbalanced by an excess of admissions with GI bleeding (thus increasing the costs and workload of the health service, and reducing the cost-effectiveness of the drug),” Loke said.

If a patient had “depression and arthritis, (both of which are very common), alarm bells would now ring in my mind and I would think carefully about which drugs to use,” Loke said. “The benefit-to-harm profile needs to be thoroughly considered, given the substantial risks of harm here.”

SOURCE: Alimentary Pharmacology and Therapeutics, October 5, 2007.


Free PDF Health Ebook...

Protect Yourself from Colon Cancer

    Simply right click the ebook title above, and choose Save As to save to your desktop!  You can find more FREE Natural Health, Wellness and Pet Ebooks at Remedies4.com!

Leave your response!

Add your comment below, or trackback from your own site. You can also subscribe to these comments via RSS.

Be nice. Keep it clean. Stay on topic. No spam.

You can use these tags:
<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>


This is a Gravatar-enabled weblog. To get your own globally-recognized-avatar, please register at Gravatar.